ImprimisRx announced findings from a randomized contralateral eye study comparing patient outcomes and preferences for combination therapy with individual eye drop medications after ocular surgery. The study, published in Clinical Ophthalmology, showed that the ImprimisRx combination drop produced similar health outcomes to multiple separately dosed drops, and that the combination drop was unanimously preferred by patients as it was easier to manage.
The prospective study was conducted at a single site with 33 patients who underwent cataract surgery with both eyes. Subjects received the combination drop (prednisolone acetate 1%, gatifloxacin 0.5%, and bromfenac sodium 0.075%) in one randomly selected eye, while the other eye received the same individual eye drop medications post-surgery. They were evaluated at day 1, 15 and 30 measuring visual acuities, refraction, intraocular pressure, macular thickness, patient pain and overall patient satisfaction.
Results showed that changes in central macular thickness were similar between groups, with only one control eye exhibiting significant macular edema. No differences in visual acuity, corneal edema, cells or flare were observed between groups. The study concluded that “a combination drop showed similar efficacy to multiple drops and was overwhelmingly preferred by subjects.”
“Enrollment for this study was relatively slow, as it was difficult to find eligible patients willing to use the three different drops instead of the combination drop; the latter is the standard of care in our clinic,” the investigator noted.
John Saharek, President of ImprimisRx, commented, “Post ocular surgery, patients are usually required to instill multiple topical drops to prevent infection, inflammation, and pain, often with a different bottle used for each drop. For some patients this can be confusing and/or can be burdensome, which could lead to non-compliance and suboptimal health outcomes. ImprimisRx formulations such as LessDrops® provide the unique ability to combine these individual ingredients into one bottle.”
Full news release: https://www.globenewswire.com/news-release/2020/07/13/2061138/0/en/Leading-Peer-Reviewed-Journal-Publishes-Clinical-Study-on-ImprimisRx-s-Combination-Prescription-Eyedrops.html