Association for Research in Vision and Ophthalmology
Fort Lauderdale, Fla. — Researchers from the Brien Holden Eye Research Centre, LV Prasad Eye Institute in India reveal the involvement of novel genes in primary open angle glaucoma (POAG) during a presentation at the 2011 Annual Meeting of the Association of Vision and Ophthalmology this week.
The study analyzed 45, 000 genes that were validated through customized genotyping of 40 candidate genes involved in inflammation and extracellular matrix (ECM) remodeling and their expression level in the aqueous humor.
Results showed differential expressions o f ̴200 genes. Cased-controlled analysis using 384 variants of 40 candidates revealed association in 5 ECM-related genes. The mean concentrations of the ECM proteins were significantly higher in the aqueous humor of POAG subjects compared to unaffected subjects.
Abstract Title: Whole Genome Expression and Candidate Gene Analysis Reveals the Involvement of Novel Genes in Primary Open Angle Glaucoma
Presentation Start/End Time: Wednesday, May 4, 2011; 1:45 – 3:30pm
Location: Hall B/C
Session Number: 456
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The Association for Research in Vision and Ophthalmology (ARVO) is the largest eye and vision research organization in the world. Members include more than 12,500 eye and vision researchers from over 80 countries. ARVO encourages and assists research, training, publication and knowledge-sharing in vision and ophthalmology. For more information, visit www.arvo.org.
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